2011/06/01 · The HTRA1 gene provides instructions for making a protein that is found in many of the body's organs and tissues.

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce ...

2024/03/31 · HtrA1 may function as a tumor suppressor by controlling the epithelial-to-mesenchymal transition, and may function in chemotherapeutic ...

Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This ...

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains.

2018/05/05 · High-temperature requirement protein A1 (HTRA1) is a serine protease secreted by a number of tissues including retinal pigment epithelium (RPE).

HTRA1 is a member of the HTRA (high temperature requirement) family of serine proteases first identified in bacteria. These proteases are characterized by a ...

2022/09/05 · HTRA1 expression is increased in synovial fluid of osteoarthritis patients and may contribute to cartilage degradation. Specific inhibition of ...

Symbol. Htra1 · Name. HtrA serine peptidase 1 · Synonyms. HtrA1, insulin-like growth factor binding protein 5 protease, L56, Prss11, RSPP11.

HTRA1 is a member of the mammalian HTRA (high temperature requirement A) serine protease family. The E. coli HTRA homolog functions as a chaperone-protease and ...