4 日前 · HTRA1 promotes transdifferentiation of normal fibroblasts to cancer-associated fibroblasts by upregulating alpha-SMA expression. HtrA1 cleaves ...
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce ...
2011/06/01 · The HTRA1 gene provides instructions for making a protein that is found in many of the body's organs and tissues.
HTRA1 (HtrA Serine Peptidase 1) is a Protein Coding gene. Diseases associated with HTRA1 include Cerebral Arteriopathy, Autosomal Recessive, With Subcortical ...
Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains.
HTRA1 is a member of the HTRA (high temperature requirement) family of serine proteases first identified in bacteria. These proteases are characterized by a ...
2018/05/05 · High‐temperature requirement protein A1 (HTRA1) is a serine protease secreted by a number of tissues including retinal pigment epithelium ...
HTRA1 disaggregates α-synuclein amyloid fibrils and converts them ...
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2024/03/18 · We report that HTRA1 inhibits aggregation of α-syn as well as FUS and TDP-43, which are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal ...
The HTRA1 gene encodes a member of a family of serine proteinases that regulate the degradation of extracellular matrix proteoglycans and bind and inhibit ...
Heterozygous HTRA1 mutations have been shown to be associated with a dominant, late-onset form of small vessel disease, without any extraneurologic symptoms.