Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), is a cell surface ...

Death Receptor 5 (DR5), a member of the TNF receptor superfamily, is a key mediator of the extrinsic apoptotic pathway. DR5 is a cell surface, ...

DR5, like other death receptors, is activated by binding to its ligand, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and initiates apoptosis ...

Jan 16, 2023 · Death receptors (DRs), mediate death and inflammation in many cell types, especially in the immune system. In a study published in Cell ...

We have isolated a new member of the tumor necrosis factor receptor (TNFR) family, designated DR5, which bears a high degree of sequence homology to DR4.

Death Receptor 5 is a type of death receptor that, when activated, induces nonapoptotic cell death with necrotic features. It is one of the receptors, ...

Nov 9, 2016 · DR5 is significantly up-regulated in CRC. Death receptor gene DR5 (TRAIL-R2) was found to be over-expressed in CRC tissues compared to normal ...

The Death Receptors belong to the TNF (Tumor Necrosis Factor) gene superfamily and generally will have several functions other than initiating apoptosis. Eight ...

The DR family which is part of the tumor necrosis factor receptor superfamily can be triggered by death ligands to result in apoptotic or survival signals.

Jul 4, 2014 · Here, we report that unmitigated ER stress promoted apoptosis through cell-autonomous, UPR-controlled activation of death receptor 5 (DR5).